Erdozain Sosa JC, Cancelas.
This article has been cited by other articles in PMC. Abstract Alcohol is a leading cause of liver disease and is associated with significant morbidity and mortality. Several factors, including the amount and duration of alcohol consumption, affect the development and progression of alcoholic liver disease ALD.
ALD represents a spectrum of liver pathology ranging from fatty change to fibrosis to cirrhosis. Early diagnosis of ALD is important to encourage alcohol abstinence, minimize the progression of liver fibrosis, and manage cirrhosis-related complications including hepatocellular carcinoma.
A number of questionnaires and laboratory tests are available to screen for alcohol intake. Liver biopsy remains the gold-standard diagnostic tool for ALD, but noninvasive accurate alternatives, including a number of biochemical tests as well as liver stiffness measurement, are increasingly being utilized in the evaluation of patients with suspected ALD.
The management of ALD depends largely on complete abstinence from alcohol. Supportive care should focus on treating alcohol withdrawal and providing enteral nutrition while managing the complications of liver failure.
Alcoholic hepatitis AH is a devastating acute form of ALD that requires early recognition and specialized tertiary medical care. Assessment of AH severity using defined scoring systems is important to allocate resources and initiate appropriate therapy.
Corticosteroids or pentoxifylline are commonly used in treating AH but provide a limited survival benefit. Liver transplantation represents the ultimate therapy for patients with alcoholic cirrhosis, with most transplant centers mandating a 6 month period of abstinence from alcohol before listing.
Early liver transplantation is also emerging as a therapeutic measure in specifically selected patients with severe AH.
A number of novel targeted therapies for ALD are currently being evaluated in clinical trials. Alcoholism, Alcoholic cirrhosis, Alcoholic hepatitis, Liver transplantation Introduction Alcohol is consumed in most regions of the world and is a leading cause of liver disease.
It is responsible for over 2. An additional 80, deaths resulted from alcohol-related hepatocellular carcinoma. The duration of alcohol intake and amount of ingested alcohol are the most important predictors for the development of ALD.
It is important to understand that ALD represents a spectrum of liver pathology that starts with fatty liver change, which is present in almost all heavy alcohol drinkers and is generally asymptomatic.Marsano et al., , reported that Alcoholic liver disease (ALD) is a serious and potentially fatal outcome caused due to alcohol usage.
ALD encompasses three conditions mainly fatty liver, alcoholic hepatitis and cirrhosis. The diagnosis and management of this disease is .
Oct 28, · Keywords: Alcoholic liver disease, Alcoholic pancreatitis, Alcohol and gastrointestinal tract Core tip: Alcohol abuse represents the world’s third largest risk factor for disease and disability.
According to a “hepatocentric” vision of the problem, liver has been considered for long time the main victim of the harmful use of alcohol. Alcoholic liver disease (ALD) is the result of liver damage caused by the excess consumption of alcohol. The liver processes what the body needs and discards what it doesn’t need, including alcohol.
Jan 16, · Phenytoin, formerly known as diphenylhydantoin, is perhaps the most commonly used major anticonvulsant agent, and is a rare but well known cause of acute idiosyncratic drug induced liver disease that can be severe and even fatal.
Jul 21, · In addition, pentoxifylline has been evaluated as the therapy of several liver diseases including acute alcoholic hepatitis and cirrhosis, nonalcoholic fatty liver disease and autoimmune liver conditions with varying results.
Patients with alcoholic liver disease (ALD) were also subjected to plasma DNA and LCM pyrosequencing. Results 26 patients with biopsy-proven NAFLD were included. Quantitative plasma DNA methylation of genome that is annotated during embryo development and serves to repress gene expression either by inhibiting the.